With its headwaters in the Beartooth-Absaroka Wilderness of Montana, a beautiful 25 mile stretch of Slough Creek flows through Yellowstone in steep canyons and open meadows before reaching the Lamar River confluence. This is a big cutthroat fly fishing area and you can expect to find them up to 16 inches. The are catch-and-release regulations in place so make sure to be aware of the current regulations.
There are very few access points and most fishermen access by hiking or horseback riding via the Slough Creek Wagon Trail.
Overall, Slough Creek is the 18th most popular fly fishing river of all 28 fly fishing spots in Wyoming.