The Slough Creek is well-known for its large cutthroat trout. On this gentle and scenic trout stream, the cutthroat trout are big, like up to 16 inches long.
The Slough Creek starts in the Beartooth-Absaroka Wilderness Area and flows about 25 miles to the confluence with the Lamar River. The route meanders south through Yellowstone National Park in steep canyons and open meadows past wildlife such as buffalo. The challenge here is access; it requires a lot of hiking but offers great rewards. A good access route is via the Slough Creek Wagon Trail which parallels the lower stretches for several miles. It accesses First Meadow (2 miles in), Second Meadow (5 miles in) and Third Meadow (8 miles in).
The main hatches are in July and August.
Overall, Slough Creek is the 16th most popular fly fishing river of all 21 fly fishing spots in Montana.