Near Irons, the Little Manistee River starts near the town of Luther and flows northwest for about 40 miles to the confluence in Lake Michigan. Many fly fishermen consider the Little Manistee to be the best steelhead fishery in Michigan. Near the headwaters, the river near Luther is pretty narrow and has overhanging trees. It is roughly 15-22 feet wide and is known for nice brook trout.
As the river nears Irons, the lower 20 miles of river to the lake are the most popular with fly fishermen due to the pools for steelhead. The river is roughly 50-75 feet wide in this section. Many consider the best sections to be found between Nine Mile Bridge and Six Mile Bridge. The main caddis season for fly fishing on the Little Manistee River is from late April to early September.
Overall, Little Manistee River is the 9th most popular fly fishing river of all 26 fly fishing spots in Michigan.