Near Thompsonville, the Betsie River is popular for its steelhead and salmon runs. It is also gaining popularity for its trout.
The upper section of the Betsie River is from the Little Betsie confluence down to the Grass Lake Creek confluence. The upper section is not very productive.
The lower section is below Grass Lake Creek and is more productive due to cool water and higher volume. There are nice deep pools and long runs. Above the Little Betsie confluence, a popular fishing access is Wallin Road Bridge. On the lower section, the stretch above Wolf Road has good fishing as well. For steelhead and salmon, try fishing below the SR115 crossing.
The caddis hatch is typically from mid-April through mid-September.
Overall, Betsie River is the 5th most popular fly fishing river of all 26 fly fishing spots in Michigan.