Near the town of Cedar Run, the Cedar Run is a freestone stream popular for its brown trout. The Cedar Run starts above the town of Leetonia and flows 11 miles through Tioga and Lycoming Counties on the way to the Pine Creek confluence near the town of Cedar Run.
The upper 4 mile section of Cedar Run from the headwaters to the Buck Run confluence is a narrow stream that can be rocky. This section is populated by wild brook trout and a few small wild brown trout. This section is accessed by Cedar Mountain Road.
The lower 7 mile section below Buck Run to the Pine Creek confluence is known as a trophy trout stream with plenty of wild brown trout in the cool waters. This typical freestone river is characterized by deep rock ledge pools and overhanging hardwood/pine trees. This section is accessed by SR3001 which parallels the stream.
The main hatch is from May to September. There are a variety of caddis, including the abundant tan caddis.
Overall, Cedar Run is the 35th most popular fly fishing river of all 49 fly fishing spots in Pennsylvania.