Near Harrisburg, the Clarks Creek is known as a challenging fly fishing stream. The headwaters of Clarks Creek are near Tower City and flows southwest parallel to SR325 for 20 miles to Susquehanna River confluence near Daupin. At the mid-point is Dehart Reservoir. Above the reservoir, fly fishermen can expect to find native brook trout, but keep in mind the Clarks Creek is narrow with lots of overhang.
The most interesting section for fly fishing the Clarks Creek is below Dehart Reservoir. It is roughly 35 feet wide and accessed nice sized stocked trout. About midway between the dam and the Susquehanna River, there is a 1.9 mile Delayed Harvest Fly Fishing Only section that ends at Iron Furnace.
Overall, Clarks Creek is the 11th most popular fly fishing river of all 49 fly fishing spots in Pennsylvania.