Near Spruce Creek, the Little Juniata River is slowly becoming popular again with fly fishermen as it gets cleaned up. Fly fishing on the Little Juniata River is known for its limestone flow, deep pools and prolific hatches.
Little Juniata River fly fishing starts to get good downstream of Tyrone south to village of Spruce Creek. The 13.5 miles downstream from Ironville east railroad bridge is designated Catch-and-Release section.
A nice stretch to explore is downstream of Spruce Creek in Rothrock State Forest through Barree Gorge due to big hatches and nice riffles.
Overall, Little Juniata River is the 28th most popular fly fishing river of all 49 fly fishing spots in Pennsylvania.