Near Ohiopyle, the Youghiogheny River is a popular tailwater fishery. The tailwater fishery that is best known stretches from the town of Confluence downstream to the town of Ohiopyle. The river is typically about 150 feet across in this section and is difficult to wade. It is especially dangerous in high water conditions. It is recommended to float this stretch. You can expect to find stocked brown trout and stocked rainbow trout. Below Ohiopyle, the river is too dangerous to float fish.
Access is provided by SR281 in Confluence and SR381 in Ohiopyle.
The main hatch is in May and June, but there are is also a yellow drake and slate drake hatch that extends through September.
Overall, Youghiogheny River is the 14th most popular fly fishing river of all 49 fly fishing spots in Pennsylvania.